RELATED: 100 Most Powerful Chicagoans | Most Powerful Ex-Chicagoans | Power Couples | Up-and-Comers | Poll: Which Powerful Chicagoan Would You Call Back First? | Quiz: Do You Know Chicago’s Power Players?

JOAN AND JOHN CUSACK
WHY: They both have serious Hollywood cred.

CHRISTOPHER AND JUDE REYES
WHY: That beer you’re drinking? Their distributorship probably got it to you.

LANA AND ANDY WACHOWSKI
WHY: Heard of the Matrix trilogy? They directed it.

RAKESH AND SWETAL PATEL
WHY: They run the biggest Indian grocery chain in the nation.

R.J. AND JERROD MELMAN
WHY: Lettuce Entertain You just keeps on growing.

Photography: (Cusack) Albert L. Ortega/Picturegroup via AP Images; (Melman) Anna Knott; (Wachowski) Jay Maidment; (Patel) John R. Boehm; (Christopher Reyes) Phil Velasquez/Chicago Tribune; (Jude Reyes) Chris Guillen